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Backcover (Xia, X. 2007. Bioinformatics and the cell. Springer)

Bioinformatics and the Cell is the first book with comprehensive numerical illustration of mathematical techniques and computational algorithms used in bioinformatics to convert the rapidly increasing molecular data into organized biological knowledge, with a focus on interactions among DNA, RNA and proteins in the cell. A sample of the illustrated algorithms includes:

  • String matching algorithms with associated statistics
  • Sequence alignment with the affine function and profile alignment for multiple sequence alignment
  • Contig assembly algorithms
  • Position weight matrix and perceptrons
  • Hidden Markov models
  • Gibbs sampler
  • Self-organizing map
  • Algorithms in molecular phylogenetics
  • EM algorithm for maximum likelihood calculation
  • Monte Carlo integration and Markov chain Monte Carlo algorithms for Bayesian inference
  • Mass deconvolution and computational methods for peptide mass fingerprinting

By rendering both mathematics and biology to numbers, this book should appeal not only to biologists, but also to mathematicians, biostatisticians, and computational scientists, especially those younger ones with an ambition to conquer the rough terrain of bioinformatics.

"Xuaha Xia's Bioinformatics and the Cell is a welcome addition to the bourgeoning field of bioinformatics text books. Xia stakes out a too-often neglected middle ground in bioinformatics by presenting a work that emphasizes methods' biological utility without eschewing algorithmic formalism. Readers will find a well-rounded presentation of bioinformatics techniques employed in genomics, transcriptomics and proteomics - unified throughout by the common theme of molecular evolution."

- I. King Jordan, School of Biology, Georgia Institute of Technology

"Bioinformatics and the Cell is a remarkable book because it integrates the more technical and mathematical aspects of bioinformatics with concrete examples of their application to current research problems in molecular and cellular biology. I believe that this broad, unified approach is made possible, in large part, by the very wide scope of Dr. Xia's own research experience. The integration of genomics, proteomics and transcriptomics into a single volume makes this book required reading for students entering the new and emerging field of Systems Biology. This is truly a path breaking book."

- Donal Hickey, Concordia University, Montreal, Quebec, Canada

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