XiaLab at University of Ottawa

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Welcome to XiaLab!

We do research and teaching in molecular evolution and phylogenetics, bioinformatics, microbial genomics, transcriptomics, statistical modelling, evolutionanry genetics and biomedical and biopharmaceutical sciences. You are welcome to join us, either as PhD, MSc or Honors students or visiting scientists

Research highlight:

Xia X. 2021. Dating the Common Ancestor from an NCBI Tree of 83688 High-Quality and Full-Length SARS-CoV-2 Genomes. Viruses 13(9),1790 https://www.mdpi.com/1262774

  1. More than half a million SARS-CoV-2 genomes have been sequenced. What is the most recent common ancestor (MRCA) of these sampled genomes?
  2. The MRCA based on a large tree of 83688 representative high-quality and full-length SARS-CoV-2 genomes was dated to mid-August, 2019.
  3. Cat-derived SARS-CoV-2 genomes yielded similar results.
  4. A new program TRAD has been developed to efficiently handle very large trees.
  5. The best method. The best software.
  6. A short layman's version is available at LinkedIn.

Please read

My new book "A mathematical primer of molecular phylogenetics"

Other news

9/8/2021: Congratulation to Bosen Jia for publishing in Agricultural Sciences:

Jia, B., Waldo, P., Conner, R., Moumen, I., Khan, N., Xia, X., Hou, A., You, F. (2021) Marsh Spot Disease and Its Causal Factor, Manganese Deficiency in Plants: A Historical and Prospective Review. Agricultural Sciences, 12, 928-948 doi: 10.4236/as.2021.129060

8/26/2021: Congratulations to Bosen Jia for publishing in the Crop Journal (Thanks to Dr. Frank You for doing the lion's share of supervision):

Jia B, Conner RL, Khan N, Hou A, Xia X, You FM. 2021. Inheritance of marsh spot disease resistance in cranberry common bean (Phaseolus vulgaris L.). The Crop Journal.

7/13/2021: Yulong Wei defended his PhD thesis. Congratulations! Yulong is moving to Yale University to be a postdoctoral fellow on viral research.

7/3/2021: Xia, X. 2021. Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines." Vaccines (Basel) 9(7).

6/21/2021: Full-text views of my 2021 Viruses paper exceeded 7000.

5/28/2021: Created a DAMBE forum to encourage discussion among DAMBE users

3/17/2021: Congratulations to Ali Tehfe and Talia Roseshter (two bright honors students) and Yulong Wei for their publication in Microorganisms:

Tehfe, A.; Roseshter, T.; Wei, Y.; Xia, X. Does Saccharomyces cerevisiae Require Specific Post-Translational Silencing against Leaky Translation of Hac1up? Microorganisms 2021, 9, 620.

3/8/2021: Kruglikov A, Rakesh M, Wei Y, Xia X. 2021. Applications of Protein Secondary Structure Algorithms in SARS-CoV-2 Research. " J Proteome Res 20:1457-1463.

1/18/2021: Wei Y, Aris P, Farookhi H & Xia X. 2021 Predicting mammalian species at risk of being infected by SARS‑CoV‑2 from an ACE2 perspective. Scientific Reports 11:1702

1/15,2021: Xia, X. 2021. Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design. Viruses 13(1), 109

12/22/2020: Wei Y, Silke J, Aris P & Xia X. Coronavirus genomes carry the signatures of their habitats. PLoS ONE 15(12): e0244025

11/22/2020: First book review of my book A mathematical primer of molecular phylogenetics" in Systematic Biology

Everything related to my 2020 MBE paper

If you come to me because of the media reports, please be informed that the paper has little similarity to what was reported by the media.

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