XiaLab at University of Ottawa

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Welcome to XiaLab!

We do research and teaching in molecular evolution and phylogenetics, bioinformatics, microbial genomics, transcriptomics, statistical modelling, evolutionary genetics and biomedical and biopharmaceutical sciences. You are welcome to join us, either as PhD, MSc or Honors students or visiting scientists

Research highlight:

For public review/comments: Xia, X. 2022. Sequence evidence that the D614G clade of SARS-CoV-2 was already circulating in northern Italy in the fall of 2019. Qeios.

The molecular mechanisms for acid resistance are truly natural marvels. They are so beautiful that I felt guilty to have aimed to reduce them to physics and chemistry.

Other news

11/6/2022: Encoutered an interesting author citation indicator from Stanford University's Meta-Research Innovation Center. It is perhaps the first one to take author contribution into consideration. In other citation inpact indicators such as H index, an author in a 200-author paper is treated the same as an author in a single-author paper. With this new index from Stanford, I was ranked at 21716 for career impact in the world.

10/18/2022: Congratulation to Parisa and Yulong for their new publication: Aris, P.; Wei, Y.; Mohamadzadeh, M.; Xia, X. Griseofulvin: An Updated Overview of Old and Current Knowledge. Molecules 2022, 27, 7034. Molecules 27, 7034.

10/16/2022: Congratulation to Alibek and Yulong for their new publication: Kruglikov A, Wei Y, Xia X 2022. Proteins from Thermophilic Thermus thermophilus Often Do Not Fold Correctly in a Mesophilic Expression System Such as Escherichia coli. ACS Omega 7:37797–37806.

8/18/2022: Published a comprehensive review on Helicobacter pylori: Xia, X. 2022. Multiple regulatory mechanisms for pH homeostasis in the gastric pathogen, Helicobacter pylori. Advances in Genetics. Academic Press.

7/26/2022: Bosen Jia successfully defended his thesis.

7/11/2022: New publication by Bosen and others: Jia, B.; Conner, R.L.; Penner, W.C.; Zheng, C.; Cloutier, S.; Hou, A.; Xia, X.; You, F.M. Quantitative Trait Locus Mapping of Marsh Spot Disease Resistance in Cranberry Common Bean (Phaseolus vulgaris L.). Int. J. Mol. Sci. 2022, 23, 7639.

6/22/2022: New publication by Mohan and others: Rakesh, M., Aris-Brosou, S. & Xia, X. 2022. Testing alternative hypotheses on the origin and speciation of Hawaiian katydids. BMC Ecol Evo 22, 83.

6/20/2022: New publication by Parisa, Yulong and others: Aris, P.; Mohamadzadeh, M.; Wei, Y.; Xia, X. 2022 In Silico Molecular Dynamics of Griseofulvin and Its Derivatives Revealed Potential Therapeutic Applications for COVID-19. Int. J. Mol. Sci. 23, 6889

5/8/2022: Found an interesting site for citation ranking.

Congratulation to Parisa and Yulong for their new publication: Aris P, Yan L, Wei Y, Chang Y, Shi B, Xia X. 2021. Conservation of griseofulvin genes in the gsf gene cluster among fungal genomes. G3 Genes|Genomes|Genetics.

11/18/2021: Xia, X. 2021 Post-Alignment Adjustment and Its Automation. Genes, 12, 1809. https://doi.org/10.3390/genes12111809

9/24/2021: I participated in a discussion on differences in COVID-19 vaccine efficacy in TheScientist

9/8/2021: Xia X. 2021. Dating the Common Ancestor from an NCBI Tree of 83688 High-Quality and Full-Length SARS-CoV-2 Genomes. Viruses 13(9),1790

9/8/2021: Congratulation to Bosen Jia for publishing in Agricultural Sciences:

Jia, B., Waldo, P., Conner, R., Moumen, I., Khan, N., Xia, X., Hou, A., You, F. (2021) Marsh Spot Disease and Its Causal Factor, Manganese Deficiency in Plants: A Historical and Prospective Review. Agricultural Sciences, 12, 928-948 doi: 10.4236/as.2021.129060

8/26/2021: Congratulations to Bosen Jia for publishing in the Crop Journal (Thanks to Dr. Frank You for doing the lion's share of supervision):

Jia B, Conner RL, Khan N, Hou A, Xia X, You FM. 2021. Inheritance of marsh spot disease resistance in cranberry common bean (Phaseolus vulgaris L.). The Crop Journal.

7/13/2021: Yulong Wei defended his PhD thesis. Congratulations! Yulong is moving to Yale University to be a postdoctoral fellow on viral research.

7/3/2021: Xia, X. 2021. Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines." Vaccines (Basel) 9(7).

6/21/2021: Full-text views of my 2021 Viruses paper exceeded 7000.

5/28/2021: Created a DAMBE forum to encourage discussion among DAMBE users

3/17/2021: Congratulations to Ali Tehfe and Talia Roseshter (two bright honors students) and Yulong Wei for their publication in Microorganisms:

Tehfe, A.; Roseshter, T.; Wei, Y.; Xia, X. Does Saccharomyces cerevisiae Require Specific Post-Translational Silencing against Leaky Translation of Hac1up? Microorganisms 2021, 9, 620.

3/8/2021: Kruglikov A, Rakesh M, Wei Y, Xia X. 2021. Applications of Protein Secondary Structure Algorithms in SARS-CoV-2 Research. " J Proteome Res 20:1457-1463.

1/18/2021: Wei Y, Aris P, Farookhi H & Xia X. 2021 Predicting mammalian species at risk of being infected by SARS‑CoV‑2 from an ACE2 perspective. Scientific Reports 11:1702

1/15,2021: Xia, X. 2021. Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design. Viruses 13(1), 109

12/22/2020: Wei Y, Silke J, Aris P & Xia X. Coronavirus genomes carry the signatures of their habitats. PLoS ONE 15(12): e0244025

Everything related to my 2020 MBE paper

If you come to me because of the media reports, please be informed that the paper has little similarity to what was reported by the media.

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