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BIO3119 Population Genetics (Fall term)

(This page is rarely updated. Please use Brightspce for updated information)

Relevant information:

  • This course is more mathematical than other biology courses.
  • Student composition: BioMed (40%), BioPharm (24%), Biology (16%), Biochem (8%), Health (8%), Other (4%)
  • In past years, 3rd- and 4th- year Biology students performed equally well in this course, but in all other programs, 3rd year students performed much worse than 4th-year students in this course. BPS students typically include the best and the worst performers in the course.
  • Syllabus
  • Reference book: Felsenstein, J. 2019. Theoretical Population Genetics (An excellent source of population genetics insights)
  • A very useful software tool for teaching population genetics: PopG

Weekly lecture schedule:

(The slide-embedded assignments are to be submitted on Tuesday in the week following the lecture.)

Wk Topic
1 Lec1: Introduction to BIO3119 Population Genetics
Lec2: Historical landmarks of population genetics
2 Lec3: Genetic variation and characterization
Lec4: Probability digression
2 Lec5: Probability distributions
Lec6: Mathematical models
4 Lec7: Hardy-Weinberg equilibrium (HWE)
Lec8: More on HWE
5 Lec9: Linkage disequilibrium (LD)
Lec10: Recombination and LD
6 Lec11: Mapping disease genes
Lec12: Disease diagnosis and Bayesian inference
7 Lec13: Inbreeding and fixation
Lec14: Individual-specific inbreeding coefficient
8 Reading week.
Reading week
9 Lec15: Genetic drift and EXCEL simulation file
Lec16: Drift and inbreeding
10 Lec17: Drift and Lec17 EXCEL file for simulation
Lec18: Modelling of migration and gene flow
11 Lec19: Drift-migration balance and admixture estimation
Lec20: Models of mutation
12 Lec21: Fixation and extinction
Lec22: Mutation, recombination, drift
13 Lec23: Natural selection
Lec24: Selection and mutation
14 Break
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